Fluorescent Probes for HOCl Detection in Living Cells

Hypochlorous acid (HOCl) plays an important role in the immune system not only protecting organism from pathogens, but also, due to its high reactivity, provoking development and complication of many diseases. Therefore, highly sensitive selective HOCl biosensors, including fluorescent probes, better understand roles living systems, is great importance. Nevertheless, there are difficulties associated with registration biological probes (chemo- photostability, cytotoxicity, fluorescence absorption characteristics, selectivity, sensitivity, etc.). Thus, new chemosensors has been relevant for years. In this review, we describe classification small-molecule detection as well summarize results chemosensors, their photophysical properties, applications. Particular attention paid achievements area over years 2016–2021. A number problems related design application formulated. Due absence a “gold standard” among which commercial unavailability or complex methods synthesis sensors well, some recommendations given regarding field chemosensor application. Trends visualization cells outlined.